RegisterLogin

NCX 466

CAT: 0804-HY-103388Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-103388Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
NCX 466 is an orally active COX-1 and COX-2 inhibitor that exhibits anti-inflammatory and analgesic effects. Additionally, NCX 466 acts as a NO donor, exerting anti-inflammatory and antioxidant effects by improving microcirculation. NCX 466 significantly reduces the levels of transforming growth factor-β (TGF-β) and oxidative stress markers (such as thiobarbituric acid reactive substances (TBARS) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) ), and it decreases leukocyte recruitment during inflammation by reducing myeloperoxidase (MPO) activity, thereby preventing bleomycin (HY-108345) -induced pulmonary fibrosis in mice[1].
CAS Number
[1262956-64-8]
UNSPSC
12352005
Target
COX; Glutathione Peroxidase; TGF-β Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; TGF-beta/Smad
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ncx-466.html
Smiles
O=C(OCCCC[C@H](O[N+]([O-])=O)CO[N+]([O-])=O)[C@H](C1=CC2=C(C=C(OC)C=C2)C=C1)C
Molecular Formula
C20H24N2O9
Molecular Weight
436.41
References & Citations
[1]Pini A, et al. Prevention of bleomycin-induced lung fibrosis in mice by a novel approach of parallel inhibition of cyclooxygenase and nitric-oxide donation using NCX 466, a prototype cyclooxygenase inhibitor and nitric-oxide donor. J Pharmacol Exp Ther. 2012 May;341 (2) :493-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2

Related Products

CatalogName
HY-U00023NCX 1000
HY-120966-01NCX 2121
HY-105455NCX-530
HY-108040NCX-6560
HY-W999603CRBN ligand-466
HY-R01215-01Hsa-miR-466 mimic
HY-RI01215-01Hsa-miR-466 inhibitor
HY-R01215A-01Hsa-miR-466 agomir
HY-RI01215A-01Hsa-miR-466 antagomir
HY-P1920CEF19, Epstein-Barr Virus latent NA-3A (458-466)

Alternative Products

CatalogName
GLM-300-10Aldehyde Magnetic Particles, 1% w/v, 25-37 µm, 10 mL
FP-3052-2Fluorescent Particles, Yellow, 1% w/v, 2.5-4.5 µm
ODT25FP-10052-4Oligo (dT)25 Fluorescent Particles, Yellow, 0.5% w/v, 8.0-12.9 µm
FP-2045-2Fluorescent Particles, Light Yellow, Mid-level Intensity, 1% w/v, 1.7-2.2 µm
TFB-3558-6KBiotin Fluorescent Particle Kit
TMX-10-10Biotin Magnetic Particles
MMFcPAK- 4068-6KGoat anti-Mouse IgG (Fc) Magnetic Blue Particle Array Kit, 6 Peaks, 1x10^7/mL, 4.0-4.9 µm
MMSFc-30-10Goat anti-Mouse IgG (Fc) Magnetic Particles, Smooth, 1% w/v, 3.0-3.9 µm
NFPPS-0852-5Nano Fluorescent Particle
PP-45-100Polystyrene Particles, 5% w/v, 4.5-4.9 µm

Popular Products