Pimaric acid

CAT: 0804-HY-N3063-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N3063-01Size:1 mg
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Description
Pimaric acid is a resin acid that has been found in A. cordata and various pines. Pimaric acid exerts anticancer effects via endoplasmic reticulum stress, caspase-dependent apoptosis, cell cycle arrest, and inhibition of cell migration in human ovarian cancer cells. Pimaric acid reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs) [1][2][3].
CAS Number
[127-27-5]
UNSPSC
12352211
Target
Apoptosis; MMP; NF-κB; p38 MAPK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pimaric-acid.html
Purity
98.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@]1(C)CCC[C@]2(C)[C@@]3([H])CC[C@@](C)(C=C)C=C3CC[C@@]12[H])O
Molecular Formula
C20H30O2
Molecular Weight
302.45
References & Citations
[1]Li W, et al. Anticancer effects of Pimaric acid is mediated via endoplasmic reticulum stress, caspase-dependent apoptosis, cell cycle arrest, and inhibition of cell migration in human ovarian cancer cells. Acta Biochim Pol. 2022 Mar 2;69 (1) :245-250. |[2]Ishida M, et al. Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles. J Pharmacol Sci. 2023 Oct;153 (2) :84-88. |[3]Suh SJ, et al. Pimaric acid from Aralia cordata has an inhibitory effect on TNF-α-induced MMP-9 production and HASMC migration via down-regulated NF-κB and AP-1. Chem Biol Interact. 2012 Aug 30;199 (2) :112-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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