Pimaric acid

• Description :

  Pimaric acid is a resin acid that has been found in A. cordata and various pines. Pimaric acid exerts anticancer effects via endoplasmic reticulum stress, caspase-dependent apoptosis, cell cycle arrest, and inhibition of cell migration in human ovarian cancer cells. Pimaric acid reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs) [1][2][3].

• UNSPSC :

  12352211

• Target :

  Apoptosis; MMP; NF-κB; p38 MAPK

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

• Field of Research :

  Cancer; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/pimaric-acid.html

• Purity :

  98.76

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C([C@]1(C)CCC[C@]2(C)[C@@]3([H])CC[C@@](C)(C=C)C=C3CC[C@@]12[H])O

• Molecular Formula :

  C20H30O2

• Molecular Weight :

  302.45

• References & Citations :

  [1]Li W, et al. Anticancer effects of Pimaric acid is mediated via endoplasmic reticulum stress, caspase-dependent apoptosis, cell cycle arrest, and inhibition of cell migration in human ovarian cancer cells. Acta Biochim Pol. 2022 Mar 2;69 (1) :245-250. |[2]Ishida M, et al. Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles. J Pharmacol Sci. 2023 Oct;153 (2) :84-88. |[3]Suh SJ, et al. Pimaric acid from Aralia cordata has an inhibitory effect on TNF-α-induced MMP-9 production and HASMC migration via down-regulated NF-κB and AP-1. Chem Biol Interact. 2012 Aug 30;199 (2) :112-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [127-27-5]