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PF470

CAT: 0804-HY-12629Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12629Size:1 Each
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Description
PF470 (PF-06297470) is a negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) with significant efficacy in Parkinson's disease models, but clinical development was halted due to potential issues found in toxicology studies.
CAS Number
1539296-45-1
Product Name Alternative
PF-06297470
UNSPSC
12352005
Hazard Statement
H302
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pf470.html
Smiles
CC1=C(C2=NN(C)C3=NC(OCC4=NC=CC=C4)=CN=C32)C=NC=C1
Molecular Formula
C18H16N6O
Molecular Weight
332.36
Precautions
P264-P270-P330-P501
References & Citations
[1]Discovery and preclinical characterization of 1-methyl-3- (4-methylpyridin-3-yl) -6- (pyridin-2-ylmethoxy) -1H-pyrazolo-[3,4-b]pyrazine (PF470) : a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
GTR19238840-01PF470

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