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PF470

CAT: 0931-T200534-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T200534-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1539296-45-1
Target
Others, GluR
Related Pathways
Neuroscience, Others
Bioactivity
PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.
Smiles
N=1C=CC(=C(C1)C2=NN(C=3N=C(OCC4=NC=CC=C4)C=NC23)C)C
Molecular Formula
C18H16N6O
Molecular Weight
332.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)pyrazolo[3,4-b]pyrazine
CAS Number1539296-45-1
PubChem CID72165213
IUPAC Name1-methyl-3-(4-methyl-3-pyridinyl)-6-(pyridin-2-ylmethoxy)pyrazolo[3,4-b]pyrazine
Molecular FormulaC18H16N6O
Molecular Weight332.4
XLogP1.6
Topological Polar Surface Area78.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity438
SMILES
CC1=C(C=NC=C1)C2=NN(C3=NC(=CN=C23)OCC4=CC=CC=N4)C
InChI
InChI=1S/C18H16N6O/c1-12-6-8-19-9-14(12)16-17-18(24(2)23-16)22-15(10-21-17)25-11-13-5-3-4-7-20-13/h3-10H,11H2,1-2H3
InChIKey
RDLSKDOSNKLEAQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)pyrazolo[3,4-b]pyrazine
CAS: 1539296-45-1
CID: 72165213
Formula: C18H16N6O
MW: 332.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight332.4
XLogP31.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass332.13855916
Monoisotopic Mass332.13855916
Topological Polar Surface Area78.6 Ų
Heavy Atom Count25
Formal Charge0
Complexity438
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19238840-01PF470

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