TNF-α-IN-6

TNF-α-IN-6

• CAS Number: 2699704-20-4
• UNSPSC Description: TNF-α-IN-6 (compound 12) is an orally effective allosteric inhibitor of TNFα (KD = 6.8 nM). TNF-α-IN-6 has anti-inflammatory effects[1].
• Target Antigen: TNF Receptor
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/tnf-α-in-6.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: N#CC1=NC=CC=C1CN(C2=NC(C3=CN=C(N4C[C@]5([H])N(C(NC5)=O)CC4)N=C3)=CC=C26)C(C)(C)C6=O
• Molecular Weight: 495.54
• References & Citations: [1]Dietrich JD, et al. Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design. J Med Chem. 2021 Jan 14;64(1):417-429.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported