INT-777

CAT: 0931-T11662L-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T11662L-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1199796-29-6

Target

GPCR19

Related Pathways

GPCR/G Protein

Purity

0.9989

Bioactivity

INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats.

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[H][C@@]12CC[C@H]([C@H](C)C[C@H](C)C(O)=O)[C@@]1(C)[C@@H](O)C[C@@]1([H])[C@@]2([H])[C@H](O)[C@H](CC)[C@]2([H])C[C@H](O)CC[C@]12C

Molecular Formula

C27H46O5

Molecular Weight

450.65

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
B4672-100	INT-777
A21168-10	INT-777 10mg
A21168-100	INT-777 100mg
A21168-25	INT-777 25mg
A21168-2	INT-777 2mg
A21168-50	INT-777 50mg
A21168-5	INT-777 5mg
A21168-1	INT-777 1mg
HY-15677A-01	INT-777 (R-enantiomer)
GTR19205573-01	INT-777 R-enantiomer

INT-777

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