INT-777

• Target :

  GPCR19

• Related Pathways :

  GPCR/G Protein

• Purity :

  0.9989

• Bioactivity :

  INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 ?M. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats.

• Smiles :

  [H][C@@]12CC[C@H]([C@H](C)C[C@H](C)C(O)=O)[C@@]1(C)[C@@H](O)C[C@@]1([H])[C@@]2([H])[C@H](O)[C@H](CC)[C@]2([H])C[C@H](O)CC[C@]12C

• Molecular Formula :

  C27H46O5

• Molecular Weight :

  450.65

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1199796-29-6