6,2',4'-Trimethoxyflavone

6,2',4'-Trimethoxyflavone

• CAS Number: 720675-74-1
• UNSPSC Description: 6,2',4'-Trimethoxyflavone is a potent aryl hydrocarbon receptor (AHR) antagonist. 6,2',4'-Trimethoxyflavone represses AHR-mediated gene induction[1].
• Target Antigen: Aryl Hydrocarbon Receptor
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/6-2-4-trimethoxyflavone.html
• Purity: 98.09
• Solubility: DMSO : 5 mg/mL (ultrasonic)
• Smiles: O=C1C=C(C2=CC=C(OC)C=C2OC)OC3=CC=C(OC)C=C13
• Molecular Weight: 312.32
• References & Citations: [1]Murray IA, et al. Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone [published correction appears in J Pharmacol Exp Ther. 2018 Nov;367(2):291]. J Pharmacol Exp Ther. 2010;332(1):135-144.|[2]Apaza T L, et al. Flavonoids of Tripodanthus acutifolius inhibit TNF-α production in LPS-activated THP-1 and B16-F10 cells. J Ethnopharmacol. 2019;242:112036.|[3]Chen WC, et al. Aryl hydrocarbon receptor modulates stroke-induced astrogliosis and neurogenesis in the adult mouse brain. J Neuroinflammation. 2019;16(1):187. Published 2019 Oct 12.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported