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6,2',4'-Trimethoxyflavone

CAT: 0804-HY-103220-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103220-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
6,2',4'-Trimethoxyflavone is a potent aryl hydrocarbon receptor (AHR) antagonist. 6,2',4'-Trimethoxyflavone represses AHR-mediated gene induction[1].
CAS Number
720675-74-1
UNSPSC
12352005
Target
Aryl Hydrocarbon Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/6-2-4-trimethoxyflavone.html
Purity
98.02
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=CC=C(OC)C=C2OC)OC3=CC=C(OC)C=C13
Molecular Formula
C18H16O5
Molecular Weight
312.32
References & Citations
[1]Murray IA, et al. Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone [published correction appears in J Pharmacol Exp Ther. 2018 Nov;367 (2) :291]. J Pharmacol Exp Ther. 2010;332 (1) :135-144.|[2]Apaza T L, et al. Flavonoids of Tripodanthus acutifolius inhibit TNF-α production in LPS-activated THP-1 and B16-F10 cells. J Ethnopharmacol. 2019;242:112036.|[3]Chen WC, et al. Aryl hydrocarbon receptor modulates stroke-induced astrogliosis and neurogenesis in the adult mouse brain. J Neuroinflammation. 2019;16 (1) :187. Published 2019 Oct 12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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