Cycloguanil (hydrochloride)

• UNSPSC Description:

  Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].

• Target Antigen:

  Drug Metabolite; Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/cycloguanil-hydrochloride.html

• Purity:

  99.92

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  NC1=NC(N)=NC(C)(N1C2=CC=C(C=C2)Cl)C.[H]Cl

• Molecular Weight:

  288.18

• References & Citations:

  [1]Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105(1):190-200.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  152-53-4