Cycloguanil

• Description :

  Cycloguanil, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].

• CAS Number :

  [516-21-2]

• UNSPSC :

  12352005

• Target :

  Drug Metabolite; Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/cycloguanil.html

• Solubility :

  10 mM in DMSO

• Smiles :

  NC1=NC(N)=NC(C)(C)N1C2=CC=C(Cl)C=C2

• Molecular Formula :

  C11H14ClN5

• Molecular Weight :

  251.72

• References & Citations :

  [1]Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105 (1) :190-200.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Plasmodium

• Citation 01 :

  Pharmaceuticals (Basel) . 2024 Sep 19;17 (9) :1234.|Antimicrob Agents Chemother. 2025 Aug 18:e0047125.|bioRxiv. 2025 March 15.