Cycloguanil-d6 (hydrochloride)
CAT:
804-HY-12784AS1-02
Size:
1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Cycloguanil-d6 (hydrochloride)
- CAS Number: 2712364-69-5
- UNSPSC Description: Cycloguanil-d6 hydrochloride is the deuterium labeled Cycloguanil hydrochloride. Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].
- Target Antigen: Drug Metabolite; Isotope-Labeled Compounds; Parasite
- Type: Isotope-Labeled Compounds
- Related Pathways: Anti-infection;Metabolic Enzyme/Protease;Others
- Field of Research: Infection
- Solubility: 10 mM in DMSO
- Smiles: [2H]C([2H])([2H])C1(N(C2=CC=C(C=C2)Cl)C(N)=NC(N)=N1)C([2H])([2H])[2H].Cl
- Molecular Weight: 294.21
- References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Matthaei J, et al. OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil. Clin Pharmacol Ther. 2019 Jan;105(1):190-200.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported