CDK8-IN-12
CAT:
804-HY-148561-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
CDK8-IN-12
- CAS Number: 2613307-67-6
- UNSPSC Description: CDK8-IN-12 is an orally active, potent CDK8 inhibitor with a Ki of 14 nM. CDK8-IN-12 has off-target kinase inhibition on GSK-3α, GSK-3β, PCK-θ with Kis of 13 nM, 4 nM, 109 nM, respectively. CDK8-IN-12 shows potent anti-proliferative effects selectively on MV4-11 cell. CDK8-IN-12 is an anti-cancer agent[1].
- Target Antigen: CDK; GSK-3; PKC
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Epigenetics;PI3K/Akt/mTOR;Stem Cell/Wnt;TGF-beta/Smad
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/cdk8-in-12.html
- Solubility: DMSO : 66.67 mg/mL (ultrasonic)
- Smiles: O=C1NCCC12CCN(C3=C(C4=CC5=CC=CC=C5O4)C=NC=C3Cl)CC2
- Molecular Weight: 381.86
- References & Citations: [1]Mingfeng Yu, et al. Potent and orally bioavailable CDK8 inhibitors: Design, synthesis, structure-activity relationship analysis and biological evaluation. Eur J Med Chem. 2021 Mar 15;214:113248.
- Shipping Conditions: Blue Ice
- Clinical Information: No Development Reported