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1-Methoxyphaseollidin

CAT: 0804-HY-N8489Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N8489Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
1-Methoxyphaseollidin, a flavonoid compound, is a lysoPAF acetyltransferase inhibitor, with an IC50 of 48 μM. 1-Methoxyphaseollidin exhibits anti-H.pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX) -sensitive strains[1][2][3].
CAS Number
65428-13-9
UNSPSC
12352005
Target
Bacterial; Endogenous Metabolite
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/1-methoxyphaseollidin.html
Purity
99.11
Solubility
DMSO : 18 mg/mL (ultrasonic; warming)
Smiles
OC1=CC(OC)=C2[C@@](OC3=C(C/C=C(C)\C)C(O)=CC=C34)([H])[C@@]4([H])COC2=C1
Molecular Formula
C21H22O5
Molecular Weight
354.40
References & Citations
[1]Fukai T, et, al. Anti-Helicobacter pylori flavonoids from licorice extract. Life Sci. 2002 Aug 9;71 (12) :1449-63. |[2]Nagumo S, et, al. Inhibition of lysoPAF acetyltransferase activity by components of licorice root. Biol Pharm Bull. 1999 Oct;22 (10) :1144-6.|[3]Sinha SK, et, al. Potential Leads from Liquorice Against SARS-CoV-2 Main Protease using Molecular Docking Simulation Studies. Comb Chem High Throughput Screen. 2021;24 (4) :591-597.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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