Products for Research Use Only
RegisterLogin

SPR741

CAT: 0804-HY-P1649-02Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-P1649-02Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SPR741 (NAB741) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741[1][2].
CAS Number
1179330-52-9
Product Name Alternative
NAB741
UNSPSC
12352209
Target
Antibiotic; Bacterial
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/spr741.html
Purity
99.08
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N[C@@H]([C@H](O)C)C(N[C@H](CO)C(N[C@@H](CCNC([C@](N1)([H])[C@H](O)C)=O)C(N[C@@H](CCN)C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCN)C1=O)=O)CCN)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O
Molecular Formula
C44H73N13O13
Molecular Weight
992.13
References & Citations
[1]Corbett D, et al. Potentiation of Antibiotic Activity by a Novel Cationic Peptide: Potency and Spectrum of Activity of SPR741. Antimicrob Agents Chemother. 2017 Jul 25;61 (8) . pii: e00200-17.|[2]Eckburg PB, et al. Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, an Intravenous Potentiator, after Single and Multiple Ascending Doses and When Combined with β-Lactam Antibiotics in Healthy Subjects. Antimicrob Agents Chemother. 2019 Aug 23;63 (9) . pii: e00892-19.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
Phase 1
Citation 01
Int J Antimicrob Agents. 2021 Nov;58 (5) :106434.|J Pharm Biomed Anal. 2024 Aug 6:250:116403.|Nature. 2022 Apr;604 (7906) :541-545.

Chemical Information

Spr-741

a novel agent with structural similarity to polymyxins that is capable of potentiating the activities of various classes of antibiotics

CAS Number1179330-52-9
PubChem CID53323381
IUPAC Name(2S,3R)-2-acetamido-3-hydroxy-N-[(2R)-3-hydroxy-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]propan-2-yl]butanamide
Molecular FormulaC44H73N13O13
Molecular Weight992.1
XLogP-4.1
Topological Polar Surface Area430
Hydrogen Bond Donor Count16
Hydrogen Bond Acceptor Count16
Rotatable Bond Count18
Heavy Atom Count70
Formal Charge0
Complexity1790
SMILES
C[C@H]([C@H]1C(=O)NCC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCN)CCN)CC(C)C)CC2=CC=CC=C2)CCN)NC(=O)[C@@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)C)O
InChI
InChI=1S/C44H73N13O13/c1-22(2)19-31-40(66)52-27(11-15-45)36(62)51-29(13-17-47)39(65)57-34(23(3)59)43(69)48-18-14-30(53-42(68)33(21-58)56-44(70)35(24(4)60)49-25(5)61)38(64)50-28(12-16-46)37(63)55-32(41(67)54-31)20-26-9-7-6-8-10-26/h6-10,22-24,27-35,58-60H,11-21,45-47H2,1-5H3,(H,48,69)(H,49,61)(H,50,64)(H,51,62)(H,52,66)(H,53,68)(H,54,67)(H,55,63)(H,56,70)(H,57,65)/t23-,24-,27+,28+,29+,30+,31+,32-,33-,34+,35+/m1/s1
InChIKey
JBFNEVNUGGFPBQ-DDMCRLCFSA-N
Chemical Structure
2D Structure
2D structure of Spr-741
CAS: 1179330-52-9
CID: 53323381
Formula: C44H73N13O13
MW: 992.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight992.1
XLogP3-4.1
Hydrogen Bond Donor Count16
Hydrogen Bond Acceptor Count16
Rotatable Bond Count18
Exact Mass991.54507943
Monoisotopic Mass991.54507943
Topological Polar Surface Area430 Ų
Heavy Atom Count70
Formal Charge0
Complexity1790
Isotope Atom Count0
Defined Atom Stereocenter Count11
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-152224SPR41
HY-12930-01SPR719
HY-P704182-01SPRR4, Mouse (His)
HY-150506SPR7
HY-RS13709SPRED1 Human Pre-designed siRNA Set A
HY-RS13721SPRY1 Human Pre-designed siRNA Set A
HY-RS13724SPRY4 Human Pre-designed siRNA Set A
HY-RS22828Spry4 Mouse Pre-designed siRNA Set A
HY-RS13719SPRR4 Human Pre-designed siRNA Set A
HY-RS28284Spry1 Rat Pre-designed siRNA Set A

Alternative Products

CatalogName
MBS5801521SPR741
GTR19030403-01SPR741 acetate
M29788SPR741 TFA
MBS5789126SPR741 TFA (1179330-52-9 free base)

Popular Products