β-Endorphin, human

• Description :

  β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist of opioid receptor, with preferred affinity for μ-opioid receptor and δ-opioid receptor; β-Endorphin, human exhibits antinociception activity.

• UNSPSC :

  12352209

• Target :

  Opioid Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/_beta_-Endorphin,_human.html

• Purity :

  98.12

• Solubility :

  H2O : 12.5 mg/mL (ultrasonic)

• Smiles :

  OC(C=C1)=CC=C1CC(N)C(NCC(NCC(NC(CC2=CC=CC=C2)C(N[C@H](CCSC)C(NC(C(O)C)C(N[C@H](CO)C(NC(CCC(O)=O)C(N[C@H](CCCCN)C(NC(CO)C(NC(CCC(N)=O)C(NC(C(O)C)C(N3[C@@H](CCC3)C(NC(CC(C)C)C(NC(C(C)C)C(NC(C(O)C)C(NC(CC(C)C)C(NC(C(NC(CCCCN)C(NC(CC(N)=O)C(NC(C)C(NC(C(C)CC)C(NC(C(C)CC)C(NC(CCCCN)C(NC(CC(N)=O)C(NC(C)C(NC(C(NC(CCCCN)C(NC(CCCCN)C(NCC(NC(C(O)=O)CCC(O)=O)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Formula :

  C158H251N39O46S

• Molecular Weight :

  3464.98

• References & Citations :

  [1]Narita M, et al. Evidence for the existence of the beta-endorphin-sensitive "epsilon-opioid receptor" in the brain: the mechanisms of epsilon-mediated antinociception. Jpn J Pharmacol. 1998 Mar;76 (3) :233-53.|[2]Luan YH, et al. Action of β-endorphin and nonsteroidal anti-inflammatory drugs, and the possible effects of nonsteroidal anti-inflammatory drugs on β-endorphin. J Clin Anesth. 2017 Feb;37:123-128.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  δ Opioid Receptor/DOR

• CAS Number :

  [61214-51-5]