U0126

• Synonyms:

  1,4-Diamino-2,3-dicyano-1,4-bis (2-aminophenylthio) -butadiene

• MDL Number:

  MFCD01861186

• Purity:

  98%

• Smiles:

  N\C(=C(/C#N)\C(=C(/N)\Sc1ccccc1N)\C#N)\Sc2ccccc2N

• Additionnal Information:

  Store at -20°C

• Storage Conditions:

  Store at -20°C

• Notes:

  Selective inhibitor of the mitogen-activated protein kinase kinases, MEK-1 and MEK-2, with 100-fold higher potency than PD 98059, but is, at most, a weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4. U0126 is an inhibitor of AP-1 transactivation in cell-based reporter assays. J. Biol. Chem. 273: 18623-18632 (1998) .

• CAS Number:

  109511-58-2