U0126

CAT: 0127-BIU1095-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0127-BIU1095-01Size:5 mg
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CAS Number
109511-58-2
Synonyms
1,4-Diamino-2,3-dicyano-1,4-bis (2-aminophenylthio) -butadiene
MDL Number
MFCD01861186
Purity
98%
Smiles
N\C(=C(/C#N)\C(=C(/N)\Sc1ccccc1N)\C#N)\Sc2ccccc2N
Additionnal Information
Store at -20°C
Storage Conditions
Store at -20°C
Notes
Selective inhibitor of the mitogen-activated protein kinase kinases, MEK-1 and MEK-2, with 100-fold higher potency than PD 98059, but is, at most, a weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4. U0126 is an inhibitor of AP-1 transactivation in cell-based reporter assays. J. Biol. Chem. 273: 18623-18632 (1998) .

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