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Hardwickiic acid

CAT: 0804-HY-N3990Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N3990Size:1 mg
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Description
Hardwickiic acid ((-) -Hardwickiic acid) is a diterpenoid compound. Hardwickiic acid can block tetrodotoxin-sensitive voltage-dependent sodium channels and possesses multiple activities such as insecticidal, antinociceptive, and neurotransmitter release-regulating effects. Hardwickiic acid can be used in the study of neurological diseases[1][2][3].
CAS Number
1782-65-6
Product Name Alternative
(-) -Hardwickiic acid; (-) -Hardwikiic acid
UNSPSC
12352005
Target
Parasite; Sodium Channel
Type
Natural Products
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hardwickiic-acid.html
Purity
99.91
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@@](CCC=C2C(O)=O)([H])[C@](C)([C@H](C)CC1)CCC3=COC=C3
Molecular Formula
C20H28O3
Molecular Weight
316.43
References & Citations
[1]Cai S, et al. (-) -Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1716-1728. |[2]Bandara BM, et al. Isolation and Insecticidal Activity of (-) -Hardwickiic Acid from Croton aromaticus. Planta Med. 1987 Dec;53 (6) :575. |[3]Pittaluga A, et al. Effects of the neoclerodane Hardwickiic acid on the presynaptic opioid receptors which modulate noradrenaline and dopamine release in mouse central nervous system. Neurochem Int. 2013 Mar;62 (4) :354-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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