Hardwickiic acid

• UNSPSC Description:

  Hardwickiic acid ((-)-Hardwikiic acid) is an antinociceptive compound that blocks Tetrodotoxin-sensitive voltage-dependent sodium channels. Hardwickiic acid shows insecticidal activity[1][2].

• Target Antigen:

  Sodium Channel

• Type:

  Natural Products

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/hardwickiic-acid.html

• Purity:

  98.0

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@]12[C@@](CCC=C2C(O)=O)([H])[C@](C)([C@H](C)CC1)CCC3=COC=C3

• Molecular Weight:

  316.43

• References & Citations:

  [1]Cai S, et al. (-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels. ACS Chem Neurosci. 2019 Mar 20;10(3):1716-1728. |[2]Bandara BM, et al. Isolation and Insecticidal Activity of (-)-Hardwickiic Acid from Croton aromaticus. Planta Med. 1987 Dec;53(6):575.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1782-65-6