Hardwickiic acid

• Description:

  Hardwickiic acid ((-) -Hardwickiic acid) is a diterpenoid compound. Hardwickiic acid can block tetrodotoxin-sensitive voltage-dependent sodium channels and possesses multiple activities such as insecticidal, antinociceptive, and neurotransmitter release-regulating effects. Hardwickiic acid can be used in the study of neurological diseases[1][2][3].

• Product Name Alternative:

  (-) -Hardwickiic acid; (-) -Hardwikiic acid

• UNSPSC:

  12352005

• Target:

  Parasite; Sodium Channel

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/hardwickiic-acid.html

• Purity:

  99.91

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@]12[C@@](CCC=C2C(O)=O)([H])[C@](C)([C@H](C)CC1)CCC3=COC=C3

• Molecular Formula:

  C20H28O3

• Molecular Weight:

  316.43

• References & Citations:

  [1]Cai S, et al. (-) -Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1716-1728. |[2]Bandara BM, et al. Isolation and Insecticidal Activity of (-) -Hardwickiic Acid from Croton aromaticus. Planta Med. 1987 Dec;53 (6) :575. |[3]Pittaluga A, et al. Effects of the neoclerodane Hardwickiic acid on the presynaptic opioid receptors which modulate noradrenaline and dopamine release in mouse central nervous system. Neurochem Int. 2013 Mar;62 (4) :354-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  1782-65-6