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Ceftiofur (sodium)

CAT: 0804-HY-B0898-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0898-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ceftiofur sodium is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur sodium exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur sodium also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6[1][2][3].
CAS Number
104010-37-9
Product Name Alternative
Sodium ceftiofur
UNSPSC
12352005
Hazard Statement
H317, H334
Target
Antibiotic; Bacterial; Interleukin Related; NF-κB; p38 MAPK; TNF Receptor
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Ceftiofur-sodium.html
Concentration
10mM
Purity
98.03
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O[Na])C(N12)=C(CSC(C3=CC=CO3)=O)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O
Molecular Formula
C19H16N5NaO7S3
Molecular Weight
545.54
Precautions
H317, H334
References & Citations
[1]Salmon SA, et al. In vitro activity of Ceftiofur and its primary metabolite, desfuroylCeftiofur, against organisms of veterinary importance. J Vet Diagn Invest. 1996 Jul;8 (3) :332-6.|[2]Ci X, et al. Ceftiofur impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-kappaB and MAPK. Biochem Biophys Res Commun. 2008 Jul 18;372 (1) :73-7.|[3]Ci X, et al. Ceftiofur regulates LPS-induced production of cytokines and improves LPS-induced survival rate in mice. Inflammation. 2008 Dec;31 (6) :422-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
β-lactam
Citation 01
Mol Syst Biol. 2022 Sep;18 (9) :e11081.|Nat Commun. 2020 Apr 14;11 (1) :1792.|Microorganisms. 2025 Apr 18;13 (4) :938.|Vet Microbiol. 2024 May:292:110046.

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