Ceftiofur (sodium)

• Description :

  Ceftiofur sodium is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur sodium exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur sodium also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6[1][2][3].

• Product Name Alternative :

  Sodium ceftiofur

• UNSPSC :

  12352005

• Hazard Statement :

  H317, H334

• Target :

  Antibiotic; Bacterial; Interleukin Related; NF-κB; p38 MAPK; TNF Receptor

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/Ceftiofur-sodium.html

• Concentration :

  10mM

• Purity :

  98.03

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(O[Na])C(N12)=C(CSC(C3=CC=CO3)=O)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O

• Molecular Formula :

  C19H16N5NaO7S3

• Molecular Weight :

  545.54

• Precautions :

  H317, H334

• References & Citations :

  [1]Salmon SA, et al. In vitro activity of Ceftiofur and its primary metabolite, desfuroylCeftiofur, against organisms of veterinary importance. J Vet Diagn Invest. 1996 Jul;8 (3) :332-6.|[2]Ci X, et al. Ceftiofur impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-kappaB and MAPK. Biochem Biophys Res Commun. 2008 Jul 18;372 (1) :73-7.|[3]Ci X, et al. Ceftiofur regulates LPS-induced production of cytokines and improves LPS-induced survival rate in mice. Inflammation. 2008 Dec;31 (6) :422-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  β-lactam

• Citation 01 :

  Mol Syst Biol. 2022 Sep;18 (9) :e11081.|Nat Commun. 2020 Apr 14;11 (1) :1792.|Microorganisms. 2025 Apr 18;13 (4) :938.|Vet Microbiol. 2024 May:292:110046.

• CAS Number :

  [104010-37-9]