Ceftiofur

• Description :

  Ceftiofur is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H317, H334

• Target :

  Antibiotic; Bacterial; Interleukin Related; NF-κB; p38 MAPK; TNF Receptor

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/ceftiofur-1.html

• Purity :

  99.81

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C(N12)=C(CSC(C3=CC=CO3)=O)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)O

• Molecular Formula :

  C19H17N5O7S3

• Molecular Weight :

  523.56

• Precautions :

  H317, H334

• References & Citations :

  [1]Salmon SA, et al. In vitro activity of Ceftiofur and its primary metabolite, desfuroylCeftiofur, against organisms of veterinary importance. J Vet Diagn Invest. 1996 Jul;8 (3) :332-6.|[2]Ci X, et al. Ceftiofur impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-kappaB and MAPK. Biochem Biophys Res Commun. 2008 Jul 18;372 (1) :73-7.|[3]Ci X, et al. Ceftiofur regulates LPS-induced production of cytokines and improves LPS-induced survival rate in mice. Inflammation. 2008 Dec;31 (6) :422-7.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Citation 01 :

  Microorganisms. 2025 Apr 18;13 (4) :938.|Vet Microbiol. 2024 May:292:110046.|Mol Syst Biol. 2022 Sep;18 (9) :e11081.|Nat Commun. 2020 Apr 14;11 (1) :1792.

• CAS Number :

  [80370-57-6]