Ceftiofur

CAT: 0804-HY-N7102-01Size: 25 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-N7102-01Size:25 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Ceftiofur is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur also inhibits the activation of NF-κB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6[1][2][3].

CAS Number

80370-57-6

UNSPSC

12352005

Hazard Statement

H317, H334

Target

Antibiotic; Bacterial; Interleukin Related; NF-κB; p38 MAPK; TNF Receptor

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ceftiofur-1.html

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C(N12)=C(CSC(C3=CC=CO3)=O)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)O

Molecular Formula

C19H17N5O7S3

Molecular Weight

523.56

Precautions

H317, H334

References & Citations

[1]Salmon SA, et al. In vitro activity of Ceftiofur and its primary metabolite, desfuroylCeftiofur, against organisms of veterinary importance. J Vet Diagn Invest. 1996 Jul;8 (3) :332-6.|[2]Ci X, et al. Ceftiofur impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-kappaB and MAPK. Biochem Biophys Res Commun. 2008 Jul 18;372 (1) :73-7.|[3]Ci X, et al. Ceftiofur regulates LPS-induced production of cytokines and improves LPS-induced survival rate in mice. Inflammation. 2008 Dec;31 (6) :422-7.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Microorganisms. 2025 Apr 18;13 (4) :938.|Vet Microbiol. 2024 May:292:110046.|Mol Syst Biol. 2022 Sep;18 (9) :e11081.|Nat Commun. 2020 Apr 14;11 (1) :1792.

Alternative Products

Catalog	Name
574465	Ceftiofur
C6701-200	Ceftiofur sodium
B1907-50	Ceftiofur HCl
527042	Ceftiofur Hydrochloride

Ceftiofur

Alternative Products

Popular Products