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SAP15

CAT: 0804-HY-P10462Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10462Size:1 Each
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Description
SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3. SAP15 has the ability to penetrate cells and is able to induce downregulation of intracellular inflammation. SAP15 inhibits inflammation by inhibiting the phosphorylation of HDAC5 and thereby reducing the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 inhibits HDAC5 and NF-κB p65 phosphorylation. In addition, SAP15 treatment increased the expression of aggrecan and type II collagen and decreased the expression of osteocalcin in LPS-induced chondrocytes. SAP15 can be used in the study of inflammation regulation and anti-inflammatory therapy of biomaterials[1].
CAS Number
1403753-45-6
Product Name Alternative
Synthetic anti-inflammatory peptide 15
UNSPSC
12352209
Target
HDAC; NF-κB
Type
Peptides
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; NF-κB
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sap15.html
Smiles
O=C(N[C@@H](CCCCN)C(N[C@@H](CS)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Molecular Formula
C68H131N31O18S3
Molecular Weight
1767.16
References & Citations
[1]Lee J Y, et al. Engineered synthetic cell penetrating peptide with intracellular anti‐inflammatory bioactivity: An in vitro and in vivo study[J]. Journal of Biomedical Materials Research Part A, 2021, 109 (10) : 2001-2016.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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