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SAP15

CAT: 0931-TP2705-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP2705-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1403753-45-6
Target
NF-κB, HDAC
Related Pathways
DNA Damage/DNA Repair, NF-κB, Chromatin/Epigenetic
Bioactivity
SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic peptide composed of 15 amino acids, derived from human beta-defensin 3, with the ability to penetrate cells and mitigate intracellular inflammation. It achieves its anti-inflammatory effects by blocking the phosphorylation of HDAC5, which in turn reduces NF-κB p65 phosphorylation. In macrophages stimulated with LPS, SAP15 suppresses the phosphorylation of both HDAC5 and NF-κB p65, demonstrating potent anti-inflammatory actions. Furthermore, treatment with SAP15 in LPS-induced chondrocytes elevates aggrecan and type II collagen levels while reducing osteocalcin expression. This peptide is valuable for exploring inflammation regulation and the development of anti-inflammatory therapies in biomaterials.
Smiles
[C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC(CN)=O)=O)CS)=O)CO)=O)[C@@H](C)O)=O)CCCNC(=N)N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CS)=O)CS)=O)CCCNC(=N)N)=O)(C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CCCCN)=O)CCCNC(=N)N
Molecular Formula
C68H131N31O18S3
Molecular Weight
1767.16
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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