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Butaprost

CAT: 0804-HY-100448A-01Size: 1 mg (12.24 mM x 200 μL in Methyl Acetate)Dry Ice: NoHazardous: No
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CAT#:0804-HY-100448A-01Size:1 mg (12.24 mM x 200 μL in Methyl Acetate)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Butaprost is a selective prostaglandin E receptor (EP2) agonist with an EC50 of 33 nM and a Ki of 2.4 μM for murine EP2 receptor. Butaprost is less activity against murine EP1, EP3 and EP4 receptors. Butaprost attenuates fibrosis by hampering TGF-β/Smad2 signalling[1][2][3].
CAS Number
69685-22-9
UNSPSC
12352211
Hazard Statement
H225, H319, H336
Target
Prostaglandin Receptor; TGF-beta/Smad
Type
Reference compound
Related Pathways
GPCR/G Protein; Stem Cell/Wnt; TGF-beta/Smad
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/butaprost.html
Concentration
12.24 mM * 200 μL in Methyl acetate
Purity
99.2
Solubility
10 mM in DMSO
Smiles
COC(CCCCCC[C@@H](C(C[C@H]1O)=O)[C@H]1/C=C/C[C@@H](C2(CCC2)CCC)O)=O
Molecular Formula
C24H40O5
Molecular Weight
408.57
Precautions
H225, H319, H336
References & Citations
[1]Yanbin Liang, et al. Upregulation of orphan nuclear receptor Nur77 following PGF (2alpha), Bimatoprost, and Butaprost treatments. Essential role of a protein kinase C pathway involved in EP (2) receptor activated Nur77 gene transcription. Br J Pharmacol. 2004 Jun;142 (4) :737-48.|[2]Michael Schou Jensen, et al. Activation of the prostaglandin E 2 EP 2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices. Acta Physiol (Oxf) . 2019 Sep;227 (1) :e13291.|[3]K Tani, et al. Design and synthesis of a highly selective EP2-receptor agonist. Bioorg Med Chem Lett. 2001 Aug 6;11 (15) :2025-8.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EP

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