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PD153035 (Hydrochloride)

CAT: 0804-HY-12013-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12013-01Size:5 mg
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Description
PD153035 Hydrochloride (SU-5271 Hydrochloride) is a potent EGFR inhibitor with Ki and IC50 of 6 and 25 pM, respectively.
CAS Number
183322-45-4
Product Name Alternative
SU-5271 (Hydrochloride) ; AG1517 (Hydrochloride) ; ZM 252868 (Hydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PD153035-Hydrochloride.html
Concentration
10mM
Purity
99.48
Solubility
DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=C(C=C(C2=C1)N=CN=C2NC3=CC(Br)=CC=C3)OC.Cl
Molecular Formula
C16H15BrClN3O2
Molecular Weight
396.67
Precautions
H302, H315, H319, H335
References & Citations
[1]Bridges AJ, et al. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4- (3-bromoanilino) -6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J Med Chem. 1996 Jan 5;39 (1) :267-76.|[2]Fry DW, et al. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science. 1994 Aug 19;265 (5175) :1093-5.|[3]Bos M, et al. PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptoractivation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin Cancer Res. 1997 Nov;3 (11) :2099-106.|[4]Kunkel MW, et al. Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice. Invest New Drugs. 1996;13 (4) :295-302.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
Citation 01
BioRxiv. 2024 Apr 4.|Biochim Biophys Acta Mol Basis Dis. 2024 Mar;1870 (3) :166981.|bioRxiv. 2025 January 18.|Cell Death Dis. 2022 Jul 25;13 (7) :647.|Elife. 2015 Feb 10:4:e05178.|Gen Comp Endocrinol. 2020 Dec 1;299:113616.|Int J Stem Cells. 2022 Nov 30;15 (4) :347-358.|J Toxicol Sci. 2023 Nov 14;48 (12) :655-663.|Nat Commun. 2018 Jun 5;9 (1) :2174.|Sci Rep. 2025 Nov 17;15 (1) :40227.

Chemical Information

PD-153035 hydrochloride

PD-153035 hydrochloride is a hydrochloride obtained by combining PD-153035 with one equivalent of hydrochloric acid. It has a role as an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an epidermal growth factor receptor antagonist. It contains a PD-153035(1+).

CAS Number183322-45-4
PubChem CID11246488
IUPAC NameN-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine;hydrochloride
Molecular FormulaC16H15BrClN3O2
Molecular Weight396.7
Topological Polar Surface Area56.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count23
Formal Charge0
Complexity360
SMILES
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC.Cl
InChI
InChI=1S/C16H14BrN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H
InChIKey
ZJOKWAWPAPMNIM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of PD-153035 hydrochloride
CAS: 183322-45-4
CID: 11246488
Formula: C16H15BrClN3O2
MW: 396.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight396.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass395.00362
Monoisotopic Mass395.00362
Topological Polar Surface Area56.3 Ų
Heavy Atom Count23
Formal Charge0
Complexity360
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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