Laduviglusib

CAT: 0804-HY-10182-01Size: 5 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-10182-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy[1][2][3].

CAS Number

252917-06-9

Product Name Alternative

CHIR-99021; CT99021

UNSPSC

12352005

Hazard Statement

H300, H312+H332, H315, H319, H335

Target

Autophagy; GSK-3; Organoid; Wnt; β-catenin

Type

Reference compound

Related Pathways

Autophagy; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/laduviglusib.html

Purity

99.76

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

N#CC1=CC=C(N=C1)NCCNC2=NC=C(C(C3=CC=C(Cl)C=C3Cl)=N2)C4=NC=C(N4)C

Molecular Formula

C22H18Cl2N8

Molecular Weight

465.34

Precautions

H300, H312+H332, H315, H319, H335

References & Citations

[1]Ring DB, et al. Selective glycogen synthase kinase 3 inhibitors potentiate activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52 (3) :588-95.|[2]Bennett CN, et al. Regulation of Wnt signaling during adipogenesis. J Biol Chem. 2002 Aug 23;277 (34) :30998-1004.|[3]Naujok O, et al. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors.BMC Res Notes. 2014 Apr 29;7:273.|[4]Wang X, et al. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep. 2015 Apr 10;5:8566.|[5]Ye S, et al. Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One. 2012;7 (4) :e35892.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

GSK-3α; GSK-3β

Citation 01

Chemical Information

Laduviglusib

CHIR 99021 is a member of the class of aminopyrimidines that is 2-aminopyrimidine substituted at positions N2, 5 and 6 by (5-cyanopyridin-2-yl)ethyl, 4-methylimidazol-2-yl and 2,4-dichlorophenyl groups respectively. It has a role as an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a cyanopyridine, a diamine, a dichlorobenzene, a member of imidazoles, an aminopyridine, an aminopyrimidine and a secondary amino compound.

CAS Number	252917-06-9
PubChem CID	9956119
IUPAC Name	6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile
Molecular Formula	C22H18Cl2N8
Molecular Weight	465.3
XLogP	4.3
Topological Polar Surface Area	115
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Heavy Atom Count	32
Formal Charge	0
Complexity	645

SMILES

CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N

InChI

InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)

InChIKey

AQGNHMOJWBZFQQ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 252917-06-9

CID: 9956119

Formula: C22H18Cl2N8

MW: 465.3

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	465.3
XLogP3	4.3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	464.1031480
Monoisotopic Mass	464.1031480
Topological Polar Surface Area	115 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	645
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
C03559	Laduviglusib trihydrochloride
T86794-01	Laduviglusib dihydrochloride
C07666-25mg	Laduviglusib (CHIR-99021)
C16218-10mM/1mL	CHIR-99021 (Laduviglusib)
A10199-50	Laduviglusib (CHIR-99021) 50mg
C08972-01	Laduviglusib (CHIR-99021) HCl

Laduviglusib

Chemical Information

Alternative Products

Popular Products