Emixustat (hydrochloride)
CAT:
804-HY-19720A-04
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Emixustat (hydrochloride)
- CAS Number: 1141934-97-5
- UNSPSC Description: Emixustat (ACU-4429) hydrochloride is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. Emixustat hydrochloride is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD)[1][2][3][4].
- Target Antigen: Others
- Type: Reference compound
- Related Pathways: Others
- Applications: Metabolism-protein/nucleotide metabolism
- Field of Research: Metabolic Disease
- Assay Protocol: https://www.medchemexpress.com/Emixustat-hydrochloride.html
- Purity: 99.29
- Solubility: DMSO : 44 mg/mL (ultrasonic;warming)
- Smiles: O[C@H](CCN)C1=CC(OCC2CCCCC2)=CC=C1.[H]Cl
- Molecular Weight: 299.84
- References & Citations: [1]Kiser PD, et al. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 2015 Jun;11(6):409-15.|[2]Kubota R, et al. Phase 1, dose-ranging study of emixustat hydrochloride (ACU-4429), a novel visual cycle modulator, in healthy volunteers. Retina. 2014 Mar;34(3):603-9.|[3]Kubota R, et al. Emixustat Reduces Metabolic Demand of Dark Activity in the Retina. Invest Ophthalmol Vis Sci. 2019 Nov 1;60(14):4924-4930.|[4]Bavik C, et al. Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity. PLoS One. 2015 May 13;10(5):e0124940.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Phase 3