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Emixustat (hydrochloride)

CAT: 0804-HY-19720A-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19720A-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Emixustat (ACU-4429) hydrochloride is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. Emixustat hydrochloride is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD) [1][2][3][4].
CAS Number
1141934-97-5
Product Name Alternative
ACU-4429 hydrochloride
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Emixustat-hydrochloride.html
Purity
99.29
Solubility
DMSO : 44 mg/mL (ultrasonic; warming)
Smiles
O[C@H](CCN)C1=CC(OCC2CCCCC2)=CC=C1.[H]Cl
Molecular Formula
C16H26ClNO2
Molecular Weight
299.84
Precautions
H302, H315, H319, H335
References & Citations
[1]Kiser PD, et al. Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 2015 Jun;11 (6) :409-15.|[2]Kubota R, et al. Phase 1, dose-ranging study of emixustat hydrochloride (ACU-4429), a novel visual cycle modulator, in healthy volunteers. Retina. 2014 Mar;34 (3) :603-9.|[3]Kubota R, et al. Emixustat Reduces Metabolic Demand of Dark Activity in the Retina. Invest Ophthalmol Vis Sci. 2019 Nov 1;60 (14) :4924-4930.|[4]Bavik C, et al. Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity. PLoS One. 2015 May 13;10 (5) :e0124940.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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