Methyl tanshinonate

• UNSPSC Description:

  Methyl tanshinonate is a tanshinone, that can be isolated from Salvia miltiorrhiza (S. miltiorrhiza) Bunge (Lamiaceae). Methyl tanshinonate is a potent inhibitor of Mpro enzyme in SARS-CoV (IC50 = 21.1 µM). Methyl tanshinonate can be used for diabetes and SARS-CoV research[1][2][3].

• Target Antigen:

  SARS-CoV

• Type:

  Natural Products

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/methyl-tanshinonate.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=C(CCC[C@]3(C)C(OC)=O)C3=CC=C2C4=C(C(C)=CO4)C1=O

• Molecular Weight:

  338.35

• References & Citations:

  [1]Kim DH, et al. Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B. Chem Biol Interact. 2017 Dec 25;278:65-73.|[2]Ni L, et al. Qualitative analysis of the roots of Salvia miltiorrhiza and Salvia yunnanensis based on NIR, UHPLC and LC-MS-MS. J Pharm Biomed Anal. 2019 Jun 5;170:295-304.|[3]Diniz LRL, et al. Bioactive Terpenes and Their Derivatives as Potential SARS-CoV-2 Proteases Inhibitors from Molecular Modeling Studies. Biomolecules. 2021 Jan 7;11(1):74.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  18887-19-9