Dalbavancin (hydrochloride)

Dalbavancin (hydrochloride)

• CAS Number: 2227366-51-8
• UNSPSC Description: Dalbavancin hydrochloride (MDL-63397 hydrochloride) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin hydrochloride inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively[1][2].
• Target Antigen: Antibiotic; Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/Dalbavancin.html
• Solubility: DMSO : 250 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
• Smiles: O[C@@H]([C@@H](O)[C@@H]1O)[C@H](O[C@@H]1CO)OC2=C(C3=CC([C@@](C4=O)([H])NC([C@@](NC([C@](NC([C@@](NC5=O)([H])C6)=O)([H])C(C=C7OC(C=C8[C@H]5NC)=C(C=C8)O)=C(C(O)=C7)Cl)=O)([H])C9=CC%10=C(O[C@H](O[C@H](C(O)=O)[C@@H](O)[C@@H]%11O)[C@@H]%11NC(CCCCCCCCC(C)C)=O)C(OC%12=CC=C6C=C%12)=C9)=O)=CC=C3O)C([C@@](NC([C@](N4)([H])[C@@H](C%13=CC=C(O%10)C(Cl)=C%13)O)=O)([H])C(NCCCN(C)C)=O)=CC(O)=C2.[H]Cl
• Molecular Weight: 1853.15
• References & Citations: [1]Heine HS, et al. Activity of dalbavancin against Bacillus anthracis in vitro and in a mouse inhalation anthrax model. Antimicrob Agents Chemother. 2010 Mar;54(3):991-6.|[2]Bennett JW, et al. Dalbavancin in the treatment of complicated skin and soft-tissue infections: a review. Ther Clin Risk Manag. 2008 Feb;4(1):31-40.Antivir Res. 2020 Jun;178:104786.|Cell Res. 2021 Jan;31(1):17-24.|The Journal of Antibiotics . 2019 Feb;72(2):114-117.|Cell Res. 2021 Jan;31(1):17-24.|Enferm Infec Micr Cl. 30 July 2022.|Eur J Orthop Surg Traumatol. 2023 Jun 4.|Sci Rep. 2022 Sep 26;12(1):16001.
• Shipping Conditions: Blue Ice
• Clinical Information: Launched