Dalbavancin

• Description:

  Dalbavancin (MDL-63397) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively[1][2].

• Product Name Alternative:

  MDL-63397; BI-397

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Antibiotic; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/dalbavancin-1.html

• Purity:

  99.65

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@@H]([C@@H](O)[C@@H]1O)[C@H](O[C@@H]1CO)OC2=C(C3=CC([C@@](C4=O)([H])NC([C@@](NC([C@](NC([C@@](NC5=O)([H])C6)=O)([H])C(C=C7OC(C=C8[C@H]5NC)=C(C=C8)O)=C(C(O)=C7)Cl)=O)([H])C9=CC%10=C(O[C@H](O[C@H](C(O)=O)[C@@H](O)[C@@H]%11O)[C@@H]%11NC(CCCCCCCCC(C)C)=O)C(OC%12=CC=C6C=C%12)=C9)=O)=CC=C3O)C([C@@](NC([C@](N4)([H])[C@@H](C%13=CC=C(O%10)C(Cl)=C%13)O)=O)([H])C(NCCCN(C)C)=O)=CC(O)=C2

• Molecular Formula:

  C88H100Cl2N10O28

• Molecular Weight:

  1816.69

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Heine HS, et al. Activity of dalbavancin against Bacillus anthracis in vitro and in a mouse inhalation anthrax model. Antimicrob Agents Chemother. 2010 Mar;54 (3) :991-6.|[2]Bennett JW, et al. Dalbavancin in the treatment of complicated skin and soft-tissue infections: a review. Ther Clin Risk Manag. 2008 Feb;4 (1) :31-40.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  Glycopeptide

• Citation 01:

  Cell Res. 2021 Jan;31 (1) :17-24.|Enferm Infec Micr Cl. 30 July 2022.|Eur J Orthop Surg Traumatol. 2023 Dec;33 (8) :3655-3659.|Sci Rep. 2022 Sep 26;12 (1) :16001.|Sci Rep. 2025 May 2;15 (1) :15346.|Antivir Res. 2020 Jun;178:104786.|Cell Res. 2021 Jan;31 (1) :17-24.|The Journal of Antibiotics . 2019 Feb;72 (2) :114-117.

• CAS Number:

  [171500-79-1]