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4-FPBUA

CAT: 0804-HY-169022Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169022Size:1 Each
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Description
4-FPBUA is a semisynthetic analog of usnic acid that can enhance cellular blood-brain barrier (BBB) function and increase the transport of Amyloid β (Aβ) across monolayer cells. 4-FPBUA is also an inhibitor of mTOR, capable of enhancing cellular Autophagy, thereby reversing BBB disruption in vivo and being utilized in research for Alzheimer's disease[1].
CAS Number
2089636-93-9
UNSPSC
12352005
Target
Autophagy; mTOR
Type
Reference compound
Related Pathways
Autophagy; PI3K/Akt/mTOR
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/4-fpbua.html
Smiles
C[C@]12C3=C(O)C(C)=C(O)C(C(/C=C/C4=CC=C(C5=CC=C(C=C5)F)C=C4)=O)=C3OC1=CC(O)=C(C2=O)C(C)=O
Molecular Formula
C31H23FO7
Molecular Weight
526.51
References & Citations
[1]Al Rihani S B, et al. The Usnic Acid Analogue 4-FPBUA Enhances the Blood–Brain Barrier Function and Induces Autophagy in Alzheimer’s Disease Mouse Models[J]. ACS Chemical Neuroscience, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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