Niranthin

• Description:

  Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis research.

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Parasite; Topoisomerase

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/niranthin.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C2C (OCO2) =CC (C[C@H] (COC) [C@@H] (COC) CC3=CC (OC) =C (C=C3) OC) =C1

• Molecular Formula:

  C24H32O7

• Molecular Weight:

  432.51

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Sayan Chowdhury, et al. The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice. EMBO Mol Med. 2012 Oct;4 (10) :1126-43.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Leishmania; Topoisomerase

• CAS Number:

  50656-77-4