Niranthin

CAT: 0804-HY-N6054-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N6054-01Size:1 mg
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Description
Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis research.
CAS Number
[50656-77-4]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Parasite; Topoisomerase
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/niranthin.html
Solubility
10 mM in DMSO
Smiles
COC1=C2C(OCO2)=CC(C[C@H](COC)[C@@H](COC)CC3=CC(OC)=C(C=C3)OC)=C1
Molecular Formula
C24H32O7
Molecular Weight
432.51
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Sayan Chowdhury, et al. The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice. EMBO Mol Med. 2012 Oct;4 (10) :1126-43.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Leishmania; Topoisomerase

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