Niranthin

• Description :

  Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis research.

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Parasite; Topoisomerase

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/niranthin.html

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=C2C(OCO2)=CC(C[C@H](COC)[C@@H](COC)CC3=CC(OC)=C(C=C3)OC)=C1

• Molecular Formula :

  C24H32O7

• Molecular Weight :

  432.51

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Sayan Chowdhury, et al. The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice. EMBO Mol Med. 2012 Oct;4 (10) :1126-43.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Leishmania; Topoisomerase

• CAS Number :

  [50656-77-4]