Niranthin

• UNSPSC Description:

  Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis research.

• Target Antigen:

  Parasite; Topoisomerase

• Type:

  Natural Products

• Related Pathways:

  Anti-infection;Cell Cycle/DNA Damage

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/niranthin.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C2C(OCO2)=CC(C[C@H](COC)[C@@H](COC)CC3=CC(OC)=C(C=C3)OC)=C1

• Molecular Weight:

  432.51

• References & Citations:

  [1]Sayan Chowdhury, et al. The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice. EMBO Mol Med. 2012 Oct;4(10):1126-43.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  50656-77-4