GSK9027

CAT: 0804-HY-103548-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-103548-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK9027, as a non-steroidal glucocorticoid receptor (GR) agonist, behaves as a partial agonist on the 2xglucocorticoid response element (GRE) reporter system, and achieves intrinsic activities relative to dexamethasone[1][2].
CAS Number
[1229096-88-1]
UNSPSC
12352005
Target
Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/gsk9027.html
Purity
98.85
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=S(CC1=CC=CC=C1)(NC2=CC=C(C3=CC4=C(N(C5=CC=C(F)C=C5)N=C4)C=C3)C(C(F)(F)F)=C2)=O
Molecular Formula
C27H19F4N3O2S
Molecular Weight
525.52
References & Citations
[1] Rider CF, et al. Cytokine-Induced Loss of Glucocorticoid Function: Effect of Kinase Inhibitors, Long-Acting β2-Adrenoceptor Agonist and Glucocorticoid Receptor Ligands. PLoS ONE. 2015; 10 (1) : e0116773.|[2]Rider, C. F., et al. TNF±-Induced Glucocorticoid Resistance: Inhibition Of Inflammatory Signalling And The Effect On Full And Partial GR Agonists. 2012
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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