Phosphatidylserine

Phosphatidylserine

• CAS Number: 1446756-47-3
• UNSPSC Description: Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses[1][2][3][4][5].
• Target Antigen: Akt; TGF-β Receptor
• Type: Reference compound
• Related Pathways: PI3K/Akt/mTOR;TGF-beta/Smad
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/phosphatidylserine.html
• Purity: 98.0
• Solubility: 10 mM in DMSO
• Smiles: [Phosphatidylserine]
• Molecular Weight: 788.10
• References & Citations: [1]Kay JG, et al. Phosphatidylserine-mediated cellular signaling. Adv Exp Med Biol. 2013;991:177-93. |[2]Hoffmann PR, et al. Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J Immunol. 2005 Feb 1;174(3):1393-404. |[3]Kim HY, et al. Phosphatidylserine in the brain: metabolism and function. Prog Lipid Res. 2014 Oct;56:1-18. |[4]Scott-Hewitt N, et al. Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia. EMBO J. 2020 Aug 17;39(16):e105380. |[5]Huang BX, et al. Phosphatidylserine is a critical modulator for Akt activation. J Cell Biol. 2011 Mar 21;192(6):979-92.
• Shipping Conditions: Blue Ice
• Storage Conditions: Solution, -20°C, 2 years
• Clinical Information: Phase 2