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Phosphatidylserine

CAT: 0804-HY-A0183-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0183-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses[1][2][3][4][5].
CAS Number
1446756-47-3
Product Name Alternative
Phospholipids, phosphatidylserines; Serine glycerophosphatides
UNSPSC
12352211
Target
Akt; TGF-β Receptor
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/phosphatidylserine.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
[Phosphatidylserine]
Molecular Formula
C42H78NO10P (for oleoyl)
Molecular Weight
788.10
References & Citations
[1]Kay JG, et al. Phosphatidylserine-mediated cellular signaling. Adv Exp Med Biol. 2013;991:177-93. |[2]Hoffmann PR, et al. Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J Immunol. 2005 Feb 1;174 (3) :1393-404. |[3]Kim HY, et al. Phosphatidylserine in the brain: metabolism and function. Prog Lipid Res. 2014 Oct;56:1-18. |[4]Scott-Hewitt N, et al. Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia. EMBO J. 2020 Aug 17;39 (16) :e105380. |[5]Huang BX, et al. Phosphatidylserine is a critical modulator for Akt activation. J Cell Biol. 2011 Mar 21;192 (6) :979-92.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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