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STING1 antibody

CAT: 0710-FNab10949Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10949Size:100 µg
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Background
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.
Synonyms
Stimulator of interferon genes protein (hSTING) |Endoplasmic reticulum interferon stimulator (ERIS) |Mediator of IRF3 activation (hMITA) |Transmembrane protein 173|STING1|ERIS|MITA|STING|TMEM173
Gene ID
340061
UniProt
Q86WV6
Host
Mouse
Reactivity
Human
Immunogen
Transmembrane protein 173
Target
STING1
Clonality
Monoclonal
Isotype
IgG2b
Applications
ELISA, WB, IHC
Purification
Protein A+G purification
Dilution
WB: 1:1000 - 1:5000; IHC: 1:100 - 1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
39 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
1G9
Tested Applications
ELISA, WB, IHC

UniProtKB · Q86WV6

Stimulator of interferon genes protein

STING_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q86WV6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
STING1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hSTING
EC number
—
Processing
—
Secondary accessions
A8K3P6, B6EB35, D6RBX0, D6RE01, D6RID9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

AutophagyHost-virus interactionImmunityInnate immunityIon transportTransport

Cellular component

Cell membraneCytoplasmCytoplasmic vesicleEndoplasmic reticulumEndosomeGolgi apparatusLysosomeMembraneMitochondrionMitochondrion outer membrane

Disease

Disease variant

PTM

Disulfide bondIsopeptide bondLipoproteinPalmitatePhosphoproteinUbl conjugation

Molecular function

Ion channel

Ligand

Nucleotide-binding

Domain

TransmembraneTransmembrane helix

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