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STIM1 antibody

CAT: 0710-FNab08320Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab08320Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
STIM1, also named as GOK, is an ER Ca2+ sensor. Upon Ca2+ store depletion, STIM1 clusters at ER–plasma membrane junctions where it interacts with and gates Ca2+-permeable Orai1 ion channels. STIM1 is implicated in tumor growth suppression and stromal-haematopoietic cell interactions. Defacts in STIM1 gene can cause immune dysfunction with impaired T-cell activation. STIM1 can inhibit L-type voltage-gated Ca (2+) channels in neurons. Temperature is an important regulator of STIM1 function.The MW of STIM1 is about 80-90 kDa which may be due to the phosphorylation or glycosylation forms. This antibody is rabbit polyclonal antibody raised against the N-terminal of human STIM1.
Synonyms
Stromal interaction molecule 1|STIM1|GOK
Gene ID
6786
UniProt
Q13586
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Stromal interaction molecule 1
Target
STIM1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP, IHC, IF, FC
Field of Research
Neuroscience, Immunology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
80 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP, IHC, IF, FC

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