LM11

CAT: 0804-HY-157975Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-157975Size:1 Each
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Description
LM11 is an inhibitor of transglutaminase 2 (TG2) with an activity of killing glioblastoma cells by maintaining TG2 in a cytotoxic conformational state[1].
UNSPSC
12352005
Target
Glutaminase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lm11.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(N(C(/C1=C/NC2=CC(CN3C(C4=C(C3=O)CCC=C4)=O)=C(C=C2)Cl)=O)C5=CC=CC(Cl)=C5)=O
Molecular Formula
C26H18Cl2N4O5
Molecular Weight
537.35
References & Citations
[1]Cody Aplin, et al. Defining the conformational states that enable transglutaminase 2 to promote cancer cell survival versus cell death. bioRxiv. 2024.|[2]Sabrina Schlienger, et al. ARF1 regulates adhesion of MDA-MB-231 invasive breast cancer cells through formation of focal adhesions. Cell Signal. 2015, 27, 3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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