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LM11A-31

CAT: 0804-HY-117088-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117088-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LM11A-31, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. LM11A-31 reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression[1][2].
CAS Number
102562-74-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lm11a-31.html
Concentration
10mM
Purity
99.88
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
CC[C@H](C)[C@H](N)C(NCCN1CCOCC1)=O
Molecular Formula
C12H25N3O2
Molecular Weight
243.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Elshaer SL, et al. Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinalvascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway. Diabetologia. 2019 Aug;62 (8) :1488-1500.|[2]Simmons DA, et al. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One. 2014 Aug 25;9 (8) :e102136.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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