10Panx

10Panx

• CAS Number: 955091-53-9
• UNSPSC Description: 10Panx is a biological active peptide. (This is a Pannexin-1 (Panx1) mimetic blocking peptide. Pannexin-1 is a recently identified membrane protein that can form gap junction-like connections allowing intercellular passage of dyes when overexpressed in two adjacent oocytes or mammalian epithelial cell lines. Blockade of pannexin-1 in macrophage endogenously expressing the ATP-gated P2X7 receptor (P2X7R) blocks the initial dye uptake, but not the ionic current, and also blocks processing and release of interleukin-1b (IL-1b) in response to P2X7R activation.)
• Target Antigen: Gap Junction Protein
• Type: Peptides
• Related Pathways: Cytoskeleton
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/10panx.html
• Purity: 99.40
• Solubility: DMSO : 10 mg/mL (ultrasonic)|H2O : 11.11 mg/mL (adjust pH to 12 with 1 M NaOH)
• Smiles: OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC([C@H](CO)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](C)NC([C@H](C)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O)=O)=O)=O)=O)=O
• Molecular Weight: 1242.34
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported