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10Panx

CAT: 0804-HY-P1137-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1137-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
10Panx is a competitive inhibitor of selective Pannexin 1 (PANX1) channels. 10Panx blocks the opening of PANX1 channels, inhibits ATP release and downstream P2X7 receptor-mediated signaling pathways, thereby reducing cell death and inflammatory responses. 10Panx can be used in the study of diseases such as neuropathic pain, inflammatory bowel disease, and Clostridioides difficile infection. 10Panx can effectively reduce mechanical hyperalgesia and enhanced C-reflexes, and inhibit the expression of pro-inflammatory factors such as IL-6[1][2][3].
CAS Number
955091-53-9
UNSPSC
12352209
Target
Gap Junction Protein
Type
Peptides
Related Pathways
Cytoskeleton
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/10panx.html
Purity
99.48
Solubility
DMSO : 6.67 mg/mL (ultrasonic) |H2O : 11.11 mg/mL (adjust pH to 12 with 1 M NaOH)
Smiles
OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC([C@H](CO)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](C)NC([C@H](C)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C58H79N15O16
Molecular Weight
1242.34
References & Citations
[1]Aresta Branco MSL, et al. The Pannexin 1 Channel and the P2X7 Receptor Are in Complex Interplay to Regulate the Release of Soluble Ectonucleotidases in the Murine Bladder Lamina Propria. Int J Mol Sci. 2023 Jun 9;24 (12) :9964.|[2]Loureiro AV, et al. Role of Pannexin-1-P2X7R signaling on cell death and pro-inflammatory mediator expression induced by Clostridioides difficile toxins in enteric glia. Front Immunol. 2022 Aug 22;13:956340.|[3]Bravo D, et al. NMDA and P2X7 Receptors Require Pannexin 1 Activation to Initiate and Maintain Nociceptive Signaling in the Spinal Cord of Neuropathic Rats. Int J Mol Sci. 2022 Jun 16;23 (12) :6705.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported

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