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Y-29794

CAT: 0804-HY-15113Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-15113Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Y-29794 is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC50 of 3 nM and a Ki of 0.95 nM. Y-29794 enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 penetrates the brain-blood barrier (BBB) [1][2].
CAS Number
129184-48-1
UNSPSC
12352005
Target
Prolyl Endopeptidase (PREP)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/y-29794-1.html
Smiles
O=C(C1=C(SCCCCCCCCN(C)C)N=C(C(C)C)C=C1)C2=CC=CS2
Molecular Formula
C23H34N2OS2
Molecular Weight
418.66
References & Citations
[1]Nakajima T, et al. Y-29794--a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain. Neurosci Lett. 1992 Jul 20;141 (2) :156-60.|[2]Perez RE, et al. Prolyl endopeptidase inhibitor Y-29794 blocks the IRS1-AKT-mTORC1 pathway and inhibits survival and in vivo tumor growth of triple-negative breast cancer. Cancer Biol Ther. 2020 Nov 1;21 (11) :1033-1040.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PREP

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Alternative Products

CatalogName
T61995-01Y-29794
B5153-10Y-29794 oxalate
MBS5784721Y-29794 Tosylate
TFA98417-01Y 29794 tosylate
A16025-5Y-29794 oxalate 5mg
A16025-25Y-29794 oxalate 25mg
A16025-10Y-29794 oxalate 10mg
A15995-25Y-29794 Tosylate 25mg
A15995-10Y-29794 Tosylate 10mg
A15995-5Y-29794 Tosylate 5mg

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