Recombinant Human CCL5, biotinylated

• Description:

  Recombinant human CCL5

• Product Name Alternative:

  rHuCCL5-biotin, Rantes

• Gene Name:

  CCL5

• UniProt:

  P13501

• Cellular Locus:

  Secreted.

• Reactivity:

  Human

• Target Antigen:

  C-C motif chemokine 5

• Target:

  CCL5ylated

• Type:

  Protein

• Applications:

  Migration assay

• Dilution:

  Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.

• Form:

  Lyophilized

• Function:

  Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. RPubMed:1380064, PubMed:15923218, PubMed:16791620, PubMed:17001303, PubMed:23979485, PubMed:8525373, PubMed:9516414}.

• Additionnal Information:

  Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.Migration Assay in cells expressing recombinant CCR5.

• Storage Conditions:

  12 months from date of receipt, -20°C to -70°C, as supplied. 1 month, -20°C to -70°C, under sterile conditions after reconstitution. Best if used immediately after reconstitution.

• Specificity:

  CCL5ylated

• Target Background:

  CCL5, also known as Regulated on Activation, Normal T-cell Expressed and Secreted (RANTES), is a proinflammatory chemokine that induces migration and activation of leukocytes, and is also implied in HIV infection. CCL5 binds to cell surface receptors CCR1, CCR3, CCR4, and CCR5. Its biological effects on leukocyte activation and HIV infections is dependent upon concentration and on the binding of cell surface glycosaminoglycans.

• CAS Number:

  9000-83-3