LIM Kinase 1 Rabbit Polyclonal Antibody

LIM Kinase 1 Rabbit Polyclonal Antibody

• Description: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
• Product Name Alternative: EC 2.7.1.37 antibody LIM domain containing protein kinase antibody LIM domain kinase 1 antibody LIM kinase antibody LIM motif containing protein kinase antibody LIMK 1 antibody LIMK antibody LIMK-1 antibody limk1 antibody LIMK1_HUMAN antibody
• Abbreviation: LIMK1
• CAS Number: 9007-83-4
• Swiss Prot: P53667 Human, P53668 Mouse, P53669 Rat
• Cellular Locus: Cytoskeleton, Nucleus, Cytoplasm, Lamellipodium.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within human LIM Kinase 1 aa 450-647.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell, IHC-P
• Positive Control: Hela cell lysate, SKOV-3 cell lysate, mouse lung tissue lysate, rat stomach tissue lysate, rat brain tissue lysate, rat heart tissue lysate, rat skeletal muscle tissue lysate, MCF-7, human liver carcinoma tissue, human colon carcinoma tissue, human breast carcinoma tissue, human stomach carcinoma tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:1,000 ;IF-Cell: 1:50-1:100 ;IHC-P: 1:50-1:200
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 73 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No