Miglitol

• Description :

  Miglitol (BAY-m1099) is an orally active antidiabetic compound that inhibits the breakdown of glycoconjugates into glucose. Miglitol inhibits glycoside hydrolase enzymes called α-glucosidases. Miglitol inhibits oxidative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. Dietary supplementation with Miglitol from pre-onset stage in OLETF rats delays the onset and development of diabetes and preserves the insulin secretory function of pancreatic islets[1][2][3][4].

• Product Name Alternative :

  BAY1099; BAY-m1099

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319

• Target :

  AMPK; Glycosidase; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/Miglitol.html

• Purity :

  98.0

• Solubility :

  H2O : ≥ 200 mg/mL

• Smiles :

  O[C@@H]1[C@@H](CO)N(CCO)C[C@H](O)[C@H]1O

• Molecular Formula :

  C8H17NO5

• Molecular Weight :

  207.22

• Precautions :

  H315, H319

• References & Citations :

  [1]Fukaya, N., et al., The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats. Eur J Pharmacol, 2009. 624 (1-3) : p. 51-7.|[2]Hirata, A., et al., Effect of miglitol, an alpha-glucosidase inhibitor, on atherogenic outcomes in balloon-injured diabetic rats. Horm Metab Res, 2009. 41 (3) : p. 213-20.|[3]Scott LJ, et al. Miglitol: a review of its therapeutic potential in type 2 diabetes mellitus. Drugs. 2000 Mar;59 (3) :521-49. |[4]Aoki C, et al. Miglitol, an anti-diabetic drug, inhibits oxidative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. J Pharmacol Sci. 2012;120 (2) :121-8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [72432-03-2]