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Miglitol

CAT: 0804-HY-B0481-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0481-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Miglitol (BAY-m1099) is an orally active antidiabetic compound that inhibits the breakdown of glycoconjugates into glucose. Miglitol inhibits glycoside hydrolase enzymes called α-glucosidases. Miglitol inhibits oxidative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. Dietary supplementation with Miglitol from pre-onset stage in OLETF rats delays the onset and development of diabetes and preserves the insulin secretory function of pancreatic islets[1][2][3][4].
CAS Number
72432-03-2
Product Name Alternative
BAY1099; BAY-m1099
UNSPSC
12352005
Hazard Statement
H315, H319
Target
AMPK; Glycosidase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Miglitol.html
Purity
98.0
Solubility
H2O : ≥ 200 mg/mL
Smiles
O[C@@H]1[C@@H](CO)N(CCO)C[C@H](O)[C@H]1O
Molecular Formula
C8H17NO5
Molecular Weight
207.22
Precautions
H315, H319
References & Citations
[1]Fukaya, N., et al., The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats. Eur J Pharmacol, 2009. 624 (1-3) : p. 51-7.|[2]Hirata, A., et al., Effect of miglitol, an alpha-glucosidase inhibitor, on atherogenic outcomes in balloon-injured diabetic rats. Horm Metab Res, 2009. 41 (3) : p. 213-20.|[3]Scott LJ, et al. Miglitol: a review of its therapeutic potential in type 2 diabetes mellitus. Drugs. 2000 Mar;59 (3) :521-49. |[4]Aoki C, et al. Miglitol, an anti-diabetic drug, inhibits oxidative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. J Pharmacol Sci. 2012;120 (2) :121-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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CatalogName
B2111-25Miglitol

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