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Agaric acid

CAT: 0804-HY-N4104-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N4104-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Agaric acid (Agaricinic Acid) is an orally active inhibitor of adenine nucleotide translocase found in specific fungi. Agaric acid can inhibit the biofilm formation of various bacteria such as Salmonella. Agaric acid can also induce mitochondrial permeability transition, prompting mitochondria to release Ca2+, disrupting the transmembrane potential, and causing mitochondrial swelling. In addition, Agaric acid can also inhibit citrate transport in liver mitochondria and participate in the inhibition of fatty acid synthesis, affecting multiple metabolic processes[1][2][3][4].
CAS Number
666-99-9
Product Name Alternative
Agaricinic Acid
UNSPSC
12352211
Target
Bacterial; Calcium Channel; Mitochondrial Metabolism
Type
Natural Products
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/agaric-acid.html
Purity
99.45
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCCCCCCC(C(O)=O)C(C(O)=O)(O)CC(O)=O
Molecular Formula
C22H40O7
Molecular Weight
416.55
References & Citations
[1]García N, et al. Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Its dependence on membrane fluidity. Mitochondrion. 2005 Aug;5 (4) :272-81.|[2]Freedland RA, et al. Agaric acid. Methods Enzymol. 1981;72:497-506.|[3]Lories B, et al. Agaric acid reduces Salmonella biofilm formation by inhibiting flagellar motility. Biofilm. 2020 May 29;2:100022.|[4]Chávez E, et al. The effect of agaric acid on citrate transport in rat liver mitochondria. Life Sci. 1978 Oct 9;23 (14) :1423-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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