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Zoledronic Acid (Standard)

CAT: 0804-HY-13777R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13777R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zoledronic Acid (Standard) is the analytical standard of Zoledronic Acid. This product is intended for research and analytical applications. Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects[1].
CAS Number
118072-93-8
Product Name Alternative
Zoledronate (Standard) ; CGP 42446 (Standard) ; CGP42446A (Standard) ; ZOL 446 (Standard)
UNSPSC
12352005
Hazard Statement
H314
Target
Apoptosis; Autophagy; Bacterial; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Apoptosis; Autophagy; Others
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/zoledronic-acid-standard.html
Smiles
OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1
Molecular Formula
C5H10N2O7P2
Molecular Weight
272.09
Precautions
P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
References & Citations
[1]Lianwei Wang, et al. Various pathways of zoledronic acid against osteoclasts and bone cancer metastasis: a brief review. BMC Cancer. 2020; 20: 1059.|[2]Hyung Joon Kim, et al. Zoledronate Enhances Osteocyte-Mediated Osteoclast Differentiation by IL-6/RANKL Axis. Int J Mol Sci. 2019 Mar; 20 (6) : 1467.|[3]Xiao-Lin Huang, et al. Zoledronic acid inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways. Int J Mol Med. 2019 Aug;44 (2) :582-592.|[4]XIN HUANG, et al. Dose-dependent inhibitory effects of zoledronic acid on osteoblast viability and function in vitro. Mol Med Rep. 2016 Jan; 13 (1) : 613-622.|[5]Samantha Pozzi, et al. High-dose zoledronic acid impacts bone remodeling with effects on osteoblastic lineage and bone mechanical properties. Clin Cancer Res. 2009 Sep 15;15 (18) :5829-39.|[6]Shea GKH, et al. Oral Zoledronic acid bisphosphonate for the treatment of chronic low back pain with associated Modic changes: A pilot randomized controlled trial. J Orthop Res. 2022 Feb 23.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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