Zoledronic Acid

• UNSPSC Description:

  Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects[1].

• Target Antigen:

  Apoptosis; Autophagy; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Apoptosis;Autophagy

• Field of Research:

  Cancer; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/zoledronic-acid.html

• Smiles:

  OC(P(O)(O)=O)(P(O)(O)=O)CN1C=CN=C1

• Molecular Weight:

  272.09

• References & Citations:

  [1]Lianwei Wang, et al. Various pathways of zoledronic acid against osteoclasts and bone cancer metastasis: a brief review. BMC Cancer. 2020; 20: 1059.|[2]Hyung Joon Kim, et al. Zoledronate Enhances Osteocyte-Mediated Osteoclast Differentiation by IL-6/RANKL Axis. Int J Mol Sci. 2019 Mar; 20(6): 1467.|[3]Xiao-Lin Huang, et al. Zoledronic acid inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways. Int J Mol Med. 2019 Aug;44(2):582-592.|[4]XIN HUANG, et al. Dose-dependent inhibitory effects of zoledronic acid on osteoblast viability and function in vitro. Mol Med Rep. 2016 Jan; 13(1): 613-622.|[5]Samantha Pozzi, et al. High-dose zoledronic acid impacts bone remodeling with effects on osteoblastic lineage and bone mechanical properties. Clin Cancer Res. 2009 Sep 15;15(18):5829-39.|[6]Shea GKH, et al. Oral Zoledronic acid bisphosphonate for the treatment of chronic low back pain with associated Modic changes: A pilot randomized controlled trial. J Orthop Res. 2022 Feb 23.ACS Nano. 2023 Jul 10.|Appl Biochem Biotechnol. 2024 Mar 25.|Bone. 2024 Aug 3:117222.|Eur J Med Chem. 2024 Dec 5.|Int Immunopharmacol. September 2022, 109030.|J Dent Sci. 2024 May 4.|Med Oncol. 2023 Apr 10;40(5):141.|Nat Commun. 2024 Mar 21;15(1):2529.|Oxid Med Cell Longev. 2021 Mar 31.|Cell Rep Methods. 2023 Oct 23;3(10):100599.|Dis Markers. 2021 Oct 15;2021:5838582.|Gut Microbes. 2023 Dec;15(2):2249143.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  118072-93-8