M-PEG12-DBCO

• Description :

  M-PEG12-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  PROTAC Linkers

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/m-peg12-dbco.html

• Purity :

  98.78

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2

• Molecular Formula :

  C44H66N2O14

• Molecular Weight :

  847.00

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, stored under nitrogen, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PEG Linkers